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Cancer Diet: Feasting on the Four Food Groups - A Mesothelioma Patient's Guide to Nutrition
At some point during our childhood we have all been told to eat our vegetables. Forcing down tasteless green beans and brussels sprouts were supposed to make us taller and stronger. Well, so it is for mesothelioma patients. Diet is often an overlooked ...
Checking for Asbestos in Your Home
If you are concerned about asbestos exposure you are not alone. Many individuals wonder if they have been exposed, and if so, what they can do to help protect their health. If you think that you have been exposed to asbestos or are looking for ways to ...
Mesothelioma: Your Health In Jeopardy
Are you at risk of Mesothelioma? If you are above 40 and have ever been exposed to asbestos continuously for more than 2 months in last 15-40 years, then you are at risk of Mesothelioma. It is a rare but deadly cancer of membrane cells, which covers ...
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Diagnosis of Sarcomatoid Mesothelioma:
The differentiation of sarcomatoid mesothelioma from other cell tumors by light microscopy is quite difficult. The role of immunohistochemistry is also not well defined in its diagnosis. Since sarcomatoid mesothelioma is not always cytokeratin-negative, the distinction between it and sarcoma is not always possible. In this context, the doctors undertook a study to investigate the utility of diagnostic immunohistochemistry for distinguishing sarcomatoid mesothelioma from its histological mimics, high-grade sarcoma and pulmonary sarcomatoid carcinoma.
For its study, the researchers stained the mesotheliomas with sarcomatoid components. They assessed the intensity and
distribution of staining with the help of a semi quantitative scale. Only tumors with unequivocal staining were considered positive for tabulation. Then they compared the immunophenotypic profiles of these tumors with 24 high-grade sarcomas. The sarcomatoid carcinomas were also stained for thyroid transcription factor-1 (TTF-1).
The study showed that Cytokeratin 5/6 stained most of the epithelioids but the sarcomatoids were rarely stained. On the other hand, Calretinin and thrombomodulin each stained 70% of sarcomatoid. All 10 sarcomatoids were negative for TTF-1. This led to the conclusion that a wide immunophenotypic overlap exists among different sarcomatoids. Cytokeratin and calretinin have the most value in differentiating different sarcomatoids. Clinicopathological data, especially information about the gross appearance of the tumor is quite important for sarcomatoid tumors. Thus, it should be noted and carefully correlated with microscopic and immunohistochemical findings.
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